解剖学和形态学
麻醉学
听力与言语-语言病理学
行为科学
心脏和心血管系统
细胞和组织工程学
临床神经病学
危重症监护医学
牙科,口腔外科和医学
皮肤病学
急诊医学
内分泌学和新陈代谢
肠胃学和肝脏学
老人病学和老年医学
卫生保健科学和服务
血液学
免疫学
传染病
综合和补充性医学
医学伦理学
医学信息学
医学实验室技术
医学,全科和内科
医学,法律
医学,研究和试验
神经系统科学
护理
营养学和饮食学
产科医学和妇科医学
肿瘤学
眼科学
整形外科学
耳鼻喉科学
病理学
儿科学
周围血管疾病
药理学和药剂学
生理学
基本医疗保健
精神病学
公共、环境和职业卫生
放射学,核医学和医学成像
康复学
生殖生物学
呼吸系统
风湿病学
运动科学
外科学
毒理学
热带医学
泌尿学和肾脏学
病毒学
老年医学
健康政策和服务
心理学,临床
abstract::Neuropeptide Y (NPY) is known to bind to at least two types of receptors (Y1 & Y2). One type (Y2) is able to bind and undergo activation by both NPY and its C-terminal fragments with good potency while the other (Y1) requires the full length of NPY for good potency. For most NPY analogs that have been examined, potenc...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90073-8
更新日期:1990-11-01 00:00:00
abstract::The neuropharmacological actions of the agonist analog D-Trp-6-LH-RH were investigated in several tests after subcutaneous administrations to male mice. The doses applied were in the range 1-1000 micrograms/kg. D-Trp-6-LH-RH doses of 10 micrograms/kg and higher induced significant analgesic effects in the hot-plate an...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90053-2
更新日期:1990-10-01 00:00:00
abstract::In an attempt to determine the localization of the messenger RNA (mRNA) encoding somatostatin in the rat retina, we studied Sprague-Dawley rats by in situ hybridization histochemistry using radiolabelled oligodeoxyribonucleotides complementary for rat somatostatin mRNA. Among the layers of retina, we found specific la...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90135-l
更新日期:1990-09-01 00:00:00
abstract::Oxytocic peptides extracted from the brain and plasma of the brushtail possum, Trichosurus vulpecula, were separated by reverse-phase high pressure lipid chromatography (HPLC) and quantified by specific radioimmunoassays for oxytocin (OT) and mesotocin (MT). The pituitary, hypothalamus and cerebral cortex were found t...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90123-g
更新日期:1990-07-01 00:00:00
abstract::125I-Neuropeptide Y (NPY) bound specifically with high affinity to rat atrial and ventricular membranes. Scatchard analysis revealed the presence of single class of binding sites in both atrial and ventricular membranes. The apparent Kd and Bmax for atrial membranes were 0.63 nM and 70 fmol/mg protein, respectively; v...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90148-r
更新日期:1990-03-01 00:00:00
abstract::In order to study the morphological localization of the endogenous benzodiazepine ligand octadecaneuropeptide (ODN) in rat brain, we have developed antibodies against this peptide. Using a radioimmunoassay for ODN, we have observed that synthetic ODN and serial dilutions of several brain areas gave parallel displaceme...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(90)90155-r
更新日期:1990-01-01 00:00:00
abstract::Intrathecal administration of VIP to the thoracic spinal cord in the urethane anaesthetized rat provoked a dose-dependent increase in heart rate without any change in arterial pressure. The cardioacceleration observed following administration of 6.5 nmol of VIP at the T9 level (n = 8) occurred within 1-2 min of admini...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90053-x
更新日期:1989-11-01 00:00:00
abstract::The selectivity of a series of opioid peptides towards the mu-, delta- and kappa-opioid receptors mediating differential inhibition of electrically-induced neurotransmitter release from rat brain slices was studied, viz. cortical [3H]noradrenaline release (inhibited via mu-receptors), striatal [3H]dopamine release (in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90065-6
更新日期:1989-08-01 00:00:00
abstract::The effects of 6-hydroxydopamine (6-OHDA) injected into either the ventral tegmental area (VTA) or the nucleus accumbens on dopamine and its metabolite DOPAC and CCK-immunoreactivity in the nucleus accumbens were studied. Measurements were made 1, 3 and 6 weeks after the lesion in both the anterior and posterior part ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90061-9
更新日期:1989-08-01 00:00:00
abstract::Rats housed individually for 7 days showed a marked decrease in motor activity when tested under intense light conditions in a novel environment as compared to group-housed rats tested under low light conditions. The ACTH analogue ORG 2766 administered into the amygdala decreased the motor activity of group-housed rat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90070-x
更新日期:1989-08-01 00:00:00
abstract::Omega Conotoxin is a peptide venom of the marine snail Conus geographus which has been postulated as a neural specific calcium channel blocker in several systems. In the present study in rat ileum strips omega-conotoxin GVIA specifically blocked neuronal responses evoked by electrical field stimulation in a dose-depen...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90078-4
更新日期:1989-05-01 00:00:00
abstract::The intracerebrally administered dynorphin-B produced not only an antinociceptive response but a motor dysfunction such as "barrel-rolling", circling, jumping or ataxia in mice. These two effects were observed in a same dose range. Both responses were also produced by a nonopioid fragment, des-Tyr-dynorphin-B. Bestati...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90082-6
更新日期:1989-05-01 00:00:00
abstract::Dermorphin (Tyr-D-Ala-Phe-Gly-Tyr-Pro-Ser-NH2), a naturally occurring peptide isolated from arboreal frog skin, is endowed with outstanding structural and biological features. It has no structural community with the sequence of mammalian opioid peptides and is a unique example of a D-aminoacid containing peptide which...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90021-8
更新日期:1989-01-01 00:00:00
abstract::Cholecystokinin (CCK) is co-localized with dopamine (DA) in mesolimbic neurons of the CNS and appears to selectively regulate the output of this system. In an attempt to characterize the nature of CCK interactions with mesolimbic DA-containing nerve terminals, we have investigated CCK regulation of [3H]DA overflow fro...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(89)90020-6
更新日期:1989-01-01 00:00:00
abstract::3H-Bradykinin binding sites with the characteristics of receptors were identified in homogenates of bovine hippocampus and PC-12 cells. The characteristics of the binding were similar in both types of tissue and paralleled those of the B2 bradykinin receptor. Following exposure to nerve growth factor for 72 hours, the...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90056-x
更新日期:1988-11-01 00:00:00
abstract::The effects of intravenous self-administration of 30 micrograms infusions of either heroin or cocaine, or saline on the concentrations of beta-endorphin-immunoreactivity (beta E-IR) in the anterior part of the rat brain limbic system were studied. Self-administration of heroin and cocaine for 5 daily sessions resulted...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90060-1
更新日期:1988-11-01 00:00:00
abstract::Guinea-pigs were chronically treated with morphine by subcutaneous implantation of a compounded morphine pellet. After 7 days, the animals were sacrificed, and the small intestine was removed and extracted for the assay of 6 neuropeptides (substance P, vasoactive intestinal peptide, galanin, dynorphin A (1-8), dynorph...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90063-7
更新日期:1988-11-01 00:00:00
abstract::The human placenta contains membrane bound opioid receptors. The binding of the antagonist naloxone and the fairly kappa-selective agonist EKC were studied in the microvillous membrane fraction. In both cases high affinity binding sites were detected with Kd values in the nanomolar range. A series of kappa-selective l...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90050-9
更新日期:1988-10-01 00:00:00
abstract::A human brain aminopeptidase, which hydrolyses low molecular weight enkephalin-containing peptides (ECPs), was purified to apparent homogeneity from the homogenate of human brain. The enzyme purification involved DEAE-cellulose chromatography and preparative polyacrylamide gel electrophoresis. The purified aminopeptid...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90033-9
更新日期:1988-08-01 00:00:00
abstract::There is now considerable evidence that putative neuropeptides are involved in epileptogenic processes. Neurotensin (NT), which affects neuronal excitability in many parts of the CNS, is potentially relevant to the kindling phenomenon, but has not previously been studied in the kindling model of epilepsy. This study c...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90014-5
更新日期:1988-02-01 00:00:00
abstract::6-Beta-fluoro-6-desoxy-oxymorphone (FOXY) is a fluorinated derivative of oxymorphone originally developed as a potential PET scanning ligand. Preliminary work (Rothman et al., Neuropeptides 4: 311-317, 1984) demonstrated that [3H]FOXY selectively labeled mu opioid binding sites with low levels of nonspecific binding. ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(88)90020-0
更新日期:1988-01-01 00:00:00
abstract::Lysine-vasopressin (LVP) at different concentrations (2 ng, 200 pg) was injected into the lateral ventricle and cisterna magna. The effect on hypothalamic self-stimulation was studied in rats. LVP (2 ng) decreased the self-stimulation rate after intracerebroventricular and cisternal application. Injection of 200 pg LV...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/s0143-4179(87)90119-3
更新日期:1987-11-01 00:00:00
abstract::Considerable evidence supports the existence of modulatory interactions between cholecystokinin and dopamine in the striatum. In order to explore further the nature of such interactions, the anatomical localization of CCK receptors in rat striatum was investigated autoradiographically following selective lesions. Infu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90014-x
更新日期:1987-08-01 00:00:00
abstract::The effects of FMRFamide on passive avoidance behaviour and electroshock-induced amnesia following intracerebroventricular administration were studied in rats. FMRFamide given immediately after the learning trial, or 20 min before the retention trial, attenuated the avoidance response, thereby impairing the consolidat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90017-5
更新日期:1987-08-01 00:00:00
abstract::In vitro structure-activity studies with cholecystokinin (CCK)/gastrin-related peptides, including C- and N-terminal fragments of CCK 26-33, were undertaken in guinea pig gallbladder and ileum. The general order of potency in both smooth muscle preparations is CCK 26-33 greater than CCK 1-33 greater than 27-33 much mu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90084-9
更新日期:1987-07-01 00:00:00
abstract::Pyroglutamyl diazomethyl ketone and N-benzyloxycarbonyl prolyl prolinal, specific inhibitors of pyroglutamyl peptidase I and prolyl endopeptidase respectively, were used to study the possible role of these enzymes in the regulation of thyrotropin releasing hormone turnover. In vitro thyrotropin releasing hormone relea...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90010-2
更新日期:1987-05-01 00:00:00
abstract::The biological and immunological properties of insulin-like material produced by brain cells from 12 day old mice, cultured in serum-free media were examined. Differences were seen in the rate of appearance, relative amounts and behaviour on HPLC between immunoreactive and biologically active insulin-like material. Ex...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90006-0
更新日期:1987-05-01 00:00:00
abstract::The effects of several protein modifying reagents, including phenoxybenzamine, N-ethylmaleimide (NEM), 5,5'-dithiobis (2-nitro)--benzoic acid (DTNB), p-chloromercuryphenyl sulfonic acid (PCMP) and p-bromophenacylbromide (PBPB), on the binding of 125I-Bolton Hunter substance P (125I-BHSP), 125I-Bolton Hunter eledoisin ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90053-9
更新日期:1987-02-01 00:00:00
abstract::Somatostatin is a neuropeptide that in several experimental models of epilepsy has been suggested to modulate epileptic activity. The purpose of the present study was to investigate the role of somatostatin in seizure phenomena. We measured the somatostatin-like immunoreactivity (SLI) by radioimmunoassay of the cister...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90027-8
更新日期:1987-01-01 00:00:00
abstract::Brain insulin receptors adsorb to and are recoverable from wheat germ agglutinin-agarose (WGA) columns. Similar results are obtained using dissuccinimidyl suberate (DSS)-crosslinked receptors or photo-affinity labeled receptors. WGA can be used for partial purification of brain insulin receptors provided the appropria...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(87)90025-4
更新日期:1987-01-01 00:00:00
abstract::Opiates have been shown to affect prolactin secretion directly at the pituitary level. However, opiate binding sites have not been characterized on anterior pituitary tissue. In the present work we show that a soluble factor present in anterior pituitary membrane preparation inhibit opiate binding on striatal membrane...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90009-0
更新日期:1986-11-01 00:00:00
abstract::Dynorphin 1-8 (DYN 1-8) and Dynorphin B (DYN B) have been immunocytochemically localized to neuronal perikarya throughout the adult rat central nervous system (CNS). In order to determine if any DYN 1-8 and DYN B immunoreactive (DYN-I) cell bodies have long projections, indirect immunofluorescence was used in combinat...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90043-0
更新日期:1986-08-01 00:00:00
abstract::HPLC techniques were used to identify peptides that possess vasopressin-like immunoreactivity in the chicken neurohypophysis. The presence of arginine vasotocin (AVT) was confirmed together with arginine vasopressin (AVP). That the presence of AVP may be confined to the chicken, and not other avian species, was conclu...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90045-4
更新日期:1986-08-01 00:00:00
abstract::In this study, we examined whether the mechanisms mediating the induction of grooming behavior by oxytocin (OT) is similar to mechanisms mediating the effects of OT on uterine contractility. Sprague-Dawley strain female rats were injected intracerebroventricularly (ICV) with OT or OT analogues and then were observed f...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90068-5
更新日期:1986-07-01 00:00:00
abstract::We have found that Neuropeptide Y is colocalized with enkephalin in bovine adrenal chromaffin cells. The two peptides can be found in the same granules in those cells where they coexist. These cells correspond to the adrenergic subpopulation of chromaffin cells since they contain the epinephrine synthetic enzyme, phen...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90025-9
更新日期:1986-05-01 00:00:00
abstract::The effects of acute and chronic treatment with LSD and acute treatment with mescaline, m-CPP, citalopram and fenfluramine on leu-enkephalin (LENK) content in rat brain were examined. The acute LSD treatment was found to decrease and chronic treatment to increase the LENK content in the frontal cortex. In the thalamus...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90028-4
更新日期:1986-05-01 00:00:00
abstract::The opioid receptor antagonists, naloxone and beta-chlornaltrexamine, were used to determine whether activation of endogenous opioid peptide containing pathways produced pharmacologically reversible opioid actions. Extracellularly recorded responses of the hippocampal CA3 pyramidal cells were evoked by stimulation of ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90074-0
更新日期:1986-01-01 00:00:00
abstract::Superfusion of the dorsal surface of the septum with artificial cerebrospinal fluid containing 10(-10) M [Arg8]-vasopressin (VP) significantly increased the negative (N) wave in field potentials (FPs) elicited in the lateral septum (LS) of rats by stimulation of the fimbria-fornix. A similar increase in the FPs negati...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(86)90078-8
更新日期:1986-01-01 00:00:00
abstract::Social conflict and defeat in mice leads to an activation of endogenous opiate systems. The effects of intracerebroventricular administration of the peptide FMRFamide (Phe-Met-Arg-Phe-NH2) and the opiate antagonist naloxone, on aggressive encounters, defeat-induced analgesia and defeat-induced feeding were examined in...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90110-6
更新日期:1985-12-01 00:00:00
abstract::Experiments were performed to determine whether the renal nerve mediates the renin release induced by intracerebroventricular administration of angiotensin II (ANG II), bradykinin (BK), leucine-enkephalin (Leu-ENK) and neurotensin (NT). In sham-operated rats, both ANG II and NT suppressed plasma renin activity (PRA), ...
journal_title:Neuropeptides
pub_type: 杂志文章
doi:10.1016/0143-4179(85)90142-8
更新日期:1985-09-01 00:00:00